Home Research Multi-factorial diseases

Complex traits & multi-factorial diseases

The identification of genes underlying complex phenotypes and multifactorial diseases is a challenging task. In spite of an explosion of genome-wide studies, a limited number of confirmed genetic variants influencing human complex diseases have been identified. In addition, their genetic contribution to a given phenotype or disease is very small, and explains only a small proportion of heritability, which is the portion of phenotypic variance explained by genetic factors. It is thought that the unexplained heritability is partly due to gene-gene and gene-environment interactions. Indeed, such interactions have been identified in some multifactorial diseases, such as asthma.

It is expected that genetic variations having either a small effect or no detectable effect individually, act through interactions with environment and/or other genes in most multifactorial diseases. The existence of gene expression profiles associated with multifactorial diseases supports this view. Also, it is very likely that a combination of genetic variants within cis-regulatory regions or epigenetic modifications can deregulate the expression of a number of genes within a molecular network, thus causing the disease.

Malaria, sepsis, and cancers are multifactorial diseases influenced by genetic and environmental factors. Here, we aim at identifying genetic variants and/or deregulated networks associated with the diseases. This will provide new insights into diagnosis and prognosis knowledge, and will allow modelling the pathological systems for malaria, sepsis, and cancers. In the continuity of the previous mandate strategy, we will magnify studies involving immune system and haematological components, and will continue studies in solid tumors as a bridgehead for the development of new high throughput analyses such as large scale epigenetic approaches. Finally, we aim at identifying some common genes and pathways involved in different diseases.


Firstname Name Status E-mail Web
abrisebarre.jpg Audrey Brisebarre PhD Student This e-mail address is being protected from spambots. You need JavaScript enabled to view it
/ariel.jpg Ariel Galindo Post Doctoral Fellow
/jimbert.jpg Jean Imbert DR2 Inserm This e-mail address is being protected from spambots. You need JavaScript enabled to view it link
bkhanperles.jpg Brigitte Kahn-Perles CR1 Inserm This e-mail address is being protected from spambots. You need JavaScript enabled to view it link
/lvanhille.jpg Laurent Vanhille Post Doctoral Fellow This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Firstname Name Status E-mail Web
rcostello.jpg Regis Costello PU-PH AP-HM This e-mail address is being protected from spambots. You need JavaScript enabled to view it link
/abachhuy.jpg Eve-Lyne Mathieu Post Doctoral Fellow This e-mail address is being protected from spambots. You need JavaScript enabled to view it
cnguyen.jpg Catherine Nguyen DR1 Inserm This e-mail address is being protected from spambots. You need JavaScript enabled to view it link
/lpradel.jpg Lydie Pradel Assistant Professor This e-mail address is being protected from spambots. You need JavaScript enabled to view it
dputhier.jpg Denis Puthier Assistant Professor This e-mail address is being protected from spambots. You need JavaScript enabled to view it link
/prihet.jpg Pascal Rihet Professor This e-mail address is being protected from spambots. You need JavaScript enabled to view it link
sspicuglia.jpg Salvatore Spicuglia CR1 Inserm This e-mail address is being protected from spambots. You need JavaScript enabled to view it link
Firstname Name Status E-mail Web
/sbaaklini.jpg Sabrina Baaklini PhD Student This e-mail address is being protected from spambots. You need JavaScript enabled to view it
cbaier.jpg Céline Baier PhD Student This e-mail address is being protected from spambots. You need JavaScript enabled to view it
/belhocine.jpg Mohamed Belhocine PhD Student This e-mail address is being protected from spambots. You need JavaScript enabled to view it
/tmldao.png Thi Mai Lan Dao PhD Student This e-mail address is being protected from spambots. You need JavaScript enabled to view it
/abachhuy.jpg Saadat HUSSAIN PhD Student
//ylabiad.jpg Yasmine Labiad PhD Student This e-mail address is being protected from spambots. You need JavaScript enabled to view it
/ymbouamboua.png Yvon Mbouamboua PhD Student This e-mail address is being protected from spambots. You need JavaScript enabled to view it
/tnnguyen.jpg Thy Ngoc Nguyen PhD Student This e-mail address is being protected from spambots. You need JavaScript enabled to view it
/mnguyen.png Hong Minh Thi Nguyen PhD Student This e-mail address is being protected from spambots. You need JavaScript enabled to view it
///rragheb.jpg Ramy Ragheb PhD Student This e-mail address is being protected from spambots. You need JavaScript enabled to view it
/abachhuy.jpg Florian Rosier PhD Student This e-mail address is being protected from spambots. You need JavaScript enabled to view it
nsakakini.jpg Nathalie Sakakini Past This e-mail address is being protected from spambots. You need JavaScript enabled to view it